Back to Nature: Combating Candida albicans Biofilm, Phospholipase and Hemolysin Using Plant Essential Oils

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dc.contributor.authorEl-Baz, Ahmed M.
dc.contributor.authorMosbah, Rasha A.
dc.contributor.authorGoda, Reham M.
dc.contributor.authorMansour, Basem
dc.contributor.authorSultana, Taranum
dc.contributor.authorDahms, Tanya E. S.
dc.contributor.authorEl-Ganiny, Amira M.
dc.date.accessioned2023-05-09T17:50:33Z
dc.date.available2023-05-09T17:50:33Z
dc.date.issued2021-01-15
dc.descriptionCopyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/)en_US
dc.description.abstractCandida albicans is the causative agent of fatal systemic candidiasis. Due to limitations of antifungals, new drugs are needed. The anti-virulence effect of plant essential oils (EOs) was evaluated against clinical C. albicans isolates including cinnamon, clove, jasmine and rosemary oils. Biofilm, phospholipase and hemolysin were assessed phenotypically. EOs were evaluated for their anti-virulence activity using phenotypic methods as well as scanning electron microscopy (SEM) and atomic force microscopy (AFM). Among the C. albicans isolates, biofilm, phospholipase and hemolysins were detected in 40.4, 86.5 and 78.8% of isolates, respectively. Jasmine oil showed the highest anti-biofilm activity followed by cinnamon, clove and rosemary oils. SEM and AFM analysis showed reduced adherence and roughness in the presence of EOs. For phospholipase, rosemary oil was the most inhibitory, followed by jasmine, cinnamon and clove oils, and for hemolysins, cinnamon had the highest inhibition followed by jasmine, rosemary and clove oils. A molecular docking study revealed major EO constituents as promising inhibitors of the Als3 adhesive protein, with the highest binding for eugenol, followed by 1,8-cineole, 2-phenylthiolane and cinnamaldehyde. In conclusion, EOs have a promising inhibitory impact on Candida biofilm, phospholipase and hemolysin production, hence EOs could be used as potential antifungals that impact virulence factors.en_US
dc.description.authorstatusFacultyen_US
dc.description.peerreviewyesen_US
dc.identifier.citationEl-Baz, A.M.; Mosbah, R.A.; Goda, R.M.; Mansour, B.; Sultana, T.; Dahms, T.E.S.; El-Ganiny, A.M. Back to Nature: Combating Candida albicans Biofilm, Phospholipase and Hemolysin Using Plant Essential Oils. Antibiotics 2021, 10, 81. https:// doi.org/10.3390/antibiotics10010081en_US
dc.identifier.doihttps:// doi.org/10.3390/antibiotics10010081
dc.identifier.urihttps://hdl.handle.net/10294/15915
dc.language.isoenen_US
dc.publisherMultidisciplinary Digital Publishing Instituteen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.subjectCandida albicansen_US
dc.subjectessential oilsen_US
dc.subjectjasmine oilen_US
dc.subjectbiofilmen_US
dc.subjectSEMen_US
dc.subjectAFMen_US
dc.subjectphospholipaseen_US
dc.subjecthemolysinen_US
dc.subjectmolecular dockingen_US
dc.titleBack to Nature: Combating Candida albicans Biofilm, Phospholipase and Hemolysin Using Plant Essential Oilsen_US
dc.typeArticleen_US
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