Photochromic Dithenylethenes: From Sunglasses to the Controlled Release of Drugs
| dc.contributor.author | Cai, James (Jianxin) | |
| dc.contributor.author | Murphy, Scott | |
| dc.date.accessioned | 2011-04-13T19:50:42Z | |
| dc.date.available | 2011-04-13T19:50:42Z | |
| dc.date.issued | 2011-04-01 | |
| dc.description.abstract | There are several classes of molecules in organic chemistry that exhibit photochromism, one of which is dithienylenthenes (DTEs). Photochromism is defined as a light-induced reversible transformation between two isomeric compounds. Upon irradiation with ultraviolet light, DTEs undergo a change in colour from colourless open-ring isomers to blue colored closed-ring isomers. This colour change is due to the extensive change in molecular geometry between their isomeric forms. The new DTE compounds that I have synthesized will be used to develop drug delivery vehicles that will release their drug cargo upon irradiation with light. Our DTEs will act as the ON/OFF switch for this delivery. These vehicles are prepared by incorporating our DTEs into the membrane of biocompatible lipid vesicles or liposomes, which are spherical, self-closed structures, composed of curved lipid bilayers which entrap part of the solvent, in which they freely float, into their interior. I have developed a new approach for the synthesis of symmetrical and asymmetrical DTE compounds. I will discuss these results and the recent synthesis of dimeric DTE molecules that will also be used in light-activated drug delivery therapies. | en_US |
| dc.description.authorstatus | Student | en_US |
| dc.description.peerreview | yes | en_US |
| dc.identifier.uri | https://hdl.handle.net/10294/3276 | |
| dc.language.iso | en | en_US |
| dc.publisher | University of Regina Graduate Students' Association | en_US |
| dc.relation.ispartofseries | Session 1.5 | en_US |
| dc.subject | Photochromism | en_US |
| dc.subject | Diethenylethenes | en_US |
| dc.subject | Synthesis | en_US |
| dc.title | Photochromic Dithenylethenes: From Sunglasses to the Controlled Release of Drugs | en_US |
| dc.type | Presentation | en_US |