Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium

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dc.contributor.authorBarrila, Jennifer
dc.contributor.authorSarker, Shameema F.
dc.contributor.authorHansmeier, Nicole
dc.contributor.authorYang, Shanshan
dc.contributor.authorBuss, Kristina
dc.contributor.authorBriones, Natalia
dc.contributor.authorPark, Jin
dc.contributor.authorDavis, Richard R.
dc.contributor.authorForsyth, Rebecca J.
dc.contributor.authorOtt, C. Mark
dc.contributor.authorSato, Kevin
dc.contributor.authorKosnik, Cristine
dc.contributor.authorYang, Anthony
dc.contributor.authorShimoda, Cheryl
dc.contributor.authorRayl, Nicole
dc.contributor.authorLy, Diana
dc.contributor.authorLandenberger, Aaron
dc.contributor.authorWilson, Stephanie D.
dc.contributor.authorYamazaki, Naoko
dc.contributor.authorSteel, Jason
dc.contributor.authorMontano, Camila
dc.contributor.authorHalden, Rolf U.
dc.contributor.authorCannon, Tom
dc.contributor.authorCastro-Wallace, Sarah L.
dc.contributor.authorNickerson, Cheryl A.
dc.date.accessioned2023-04-28T15:33:07Z
dc.date.available2023-04-28T15:33:07Z
dc.date.issued2021-03-09
dc.description© The Author(s) 2021. Published by Nature Research. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons. org/licenses/by/4.0/.en_US
dc.description.abstractSpaceflight uniquely alters the physiology of both human cells and microbial pathogens, stimulating cellular and molecular changes directly relevant to infectious disease. However, the influence of this environment on host–pathogen interactions remains poorly understood. Here we report our results from the STL-IMMUNE study flown aboard Space Shuttle mission STS-131, which investigated multi-omic responses (transcriptomic, proteomic) of human intestinal epithelial cells to infection with Salmonella Typhimurium when both host and pathogen were simultaneously exposed to spaceflight. To our knowledge, this was the first in-flight infection and dual RNA-seq analysis using human cells.en_US
dc.description.authorstatusFacultyen_US
dc.description.peerreviewyesen_US
dc.description.sponsorshipNASA Space Biology NNX09AH40G, 80NSSC18K1478.en_US
dc.identifier.citationBarrila, J., Sarker, S.F., Hansmeier, N. et al. Evaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimurium. npj Microgravity 7, 9 (2021). https://doi.org/10.1038/s41526-021-00136-wen_US
dc.identifier.urihttps://hdl.handle.net/10294/15889
dc.publisherNature Researchen_US
dc.rightsAttribution 4.0 International*
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/*
dc.titleEvaluating the effect of spaceflight on the host–pathogen interaction between human intestinal epithelial cells and Salmonella Typhimuriumen_US
dc.typeArticleen_US
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